6,7 Dihydroxybergamottin is a furanocoumarin. This ingredient is generally present in grapefruit. It is also present in bergamot oil from which it derives its name. To a lesser extent it is even available in other citrus fruits and essential oils. Consuming 6, 7 dihydroxybergamottin supplements have an affect on the metabolism of various pharmaceutical drugs. 6, 7 Dihydroxybergamottin inhibits isforms of cytochrome P450 enzyme, especially CYP3A4. It is because of this feature that the enzyme prevents oxidative metabolism of some drugs, which results in accumulation of the drug in the bloodstream. According to some clinical studies 6, 7 dihydroxybergamottin hamper the body’s ability to digest caffeine, thereby extending its presence in the body. Patients under medication must therefore avoid consuming grapefruit and related supplements.

Caffeine is extracted from coffee and tea during the process of decaffeination. Caffeine Anhydrous can be produced from dimethyl urea and malonic acid. It stimulates the central nervous system, enhancing the focus, concentration, and alertness, and warding off drowsiness. It is a mild diuretic and can also increase the metabolism. It increases the energy level and reduces fatigue. Aside from increasing mental alertness, it also helps in maximizing weight loss training. It stimulates the metabolism that helps the body to burn fat faster and uses the fat as energy. It also provides physical energy and delays the onset of fatigue.

Capsaicin is used in several skin preparations and is used to relieve pain. It is available in the market in various forms such as ointments, creams, gels, liquids, lotions, sticks and pads under marketing names such as Capsagel, Zostrix, Arthricare for Women and Icy Hot Arthritis Treatment. A very astonishing fact is that capsaicin happens to be the active part of chili peppers. Though it is an irritant producing burning sensation on any tissue that comes in contact with it, it depletes substance P. Substance P transmits impulses of pan to the brain. It relieves pain due to diseases such as osteoarthritis, diabetes neuropathy and rheumatic arthritis. Capsaicin has not had any drug interactions till date. But this does not means that it can never have any interaction with any other drug. It is always best to confirm with your doctor if you really need to use capsaicin. Also, it is best to use this drug only in specified quantities.

Yerba Matte has a level of caffeine and is therefore a stimulant aids in toning, balancing and strengthening the body, aids in digestion, calms and balances nerves and is also used to help treat allergies and sinusitis.

Yohimbine HCL is a bark and is appropriate for sexual dysfunction. This is the best for erection problems as it has alkaloids. The alkaloids possess medicinal properties and are used in drugs. Yohimbine meant the chemical found on the Yohimbe bark. This belongs to the chemical family called alkaloids. Yohimbine effects are impressive. Yohimbine is used since many centuries for sexual enhancement. This bark is now sold in alkaloid concentrations such as 4%, 8% and so on up to 20%. The higher is the concentration, the more is the potent. There are companies promoting it for weight loss as well. Yohimbine HCL exhibits side effects in the form of anxiety. This bark is dangerous when consumed in excessive amounts. Higher oral doses create numerous side effects like high blood pressure, rapid heart rate and over stimulation. It also causes sleeplessness and insomnia in users. It is best to take this only after the consultation of a physician or should be taken in minimal quantities.