Grape seed is the seeds of the ordinary grapes. They are used primarily because they have polyphenols recognized as anti oxidants. Research confirms numerous health benefits of grape seed extracts; they limit lipid oxidation, thus controlling high blood pressure and high cholesterol levels. Grape seeds contain phenolics, which are useful in treatment of heart disease because they inhibit platelet aggregation and reduce inflammation, however, the results are preliminary and more research is being done to confirm these facts. A polyphenol contained in grape seeds is resveratrol which may inhibit cancer cell growth and proliferation, and it may also be active against HIV by inhibiting expression and replication of the genome of the virus.

Grape Skin Extract is extracted from the skin of grapes. Grape skin extracts, particularly red grape skin extracts, are becoming popular in medicine and nutritional supplements because some recent researches have indicated that polyphenolic extracts of red grape skin can prevent and inhibit angiogenesis, and decreases the basal motility of endothelial and cancerous cells because it has inhibitory effects on the vascular endothelial growth factor and the enzyme sphingosine- 1 - phosphate, thus preventing diseases related to angiogenesis deregulation. These diseases frequently include cancers and malignant brain tumors.

Pine Bark is known for its various nutritional properties. It is commonly used as a supplement for its preventive and healing purposes. It contains bioflavonoids, procyanidins and various vitamins. It has anti-inflammatory and anti-thrombotic effects that are beneficial to those with acute and chronic haemorrhoids. It also helps reduce joint pains and stiffness caused by osteoarthritis. Pine Bark helps other vitamins and minerals become more effective in the body. It also contains antioxidants that help in repairing and protecting the cells in the body. They fight against the damages that free radicals cause the body and cells; this helps in fighting against heart disease and cancer.

Resveratrol (trans-resveratrol) is a phytoalexin produced naturally by several plants when they are attack by pathogens. It is also produced synthetically and sold as a supplement. Resveratrol is a polyphenolic phytoalexin, its chemical formula is C14H12O3 and Mol. Mass is 228.24 g mol-1. Research shows that Resveratol has anti-inflammatory and anti-cancer effects. Some studies also reported that it can lower elevated blood sugar levels; however, in majority of these experiments mice were the test subjects and its effects are yet to be replicated in humans. Experiments on nematode worms, fruit flies and short-lived fish have shown that Resveratrol can increase life span, but it did not increase the life span of mice.