Acetyl L-Carnitine is a form of L-carnitine, only acetylated. It is a very popular dietary supplement derived from amino acids, methionine and lysine. L-carnitine helps fatty acids to cross the membrane of the mitochondria and become available for usage. ALCAR, which is an alternate name for acetyl L-carnitine, is currently under research for possible treatment of Parkinson’s disease and cerebral ischemia. Neuroprotective benefits have been already attributed to ALCAR, but also assistance in cases of Peyronie’s disease, strokes and in treatment of depression. In food it is very much present in Beef and other red meats, in smaller quantities in mushrooms and carrots. Scientific studies have verified that regular supplements of L-carnitine improve the energy metabolism and can promote the neurotransmitter functions in brains of elderly people.

Vitamin B6, which active form pyridoxal phosphate or otherwise known as PLP and pyridoxal-5’-phosphate, is a prosthetic group of tightly bound cofactors responsible for many reactions within the amino acid metabolism and the manipulation of the enzymatic reaction behind the release of glucose from glycogen. Vitamin B6 generally comprises three organic compounds, pyridoxine, pyridoxal and pyridoxamine, all of them heterocyclic organic compounds that are converted in the human body to the active pyridoxal phosphate form. There are three reactions attributed to PLP, namely transamination, alpha elimination and beta elimination. Over one hundred and forty enzyme activities depend on pyridoxal phosphate, neurotransmitter and histamine synthesis, synthesis and function of hemoglobin, and gene expression. As a cofactor, PLP is active in amino acid metabolism, glucogenesis and lipid metabolism.